Immunological response in health care workers post COVID-19 vaccination

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Original Article

Author Details : Kanwardeep Singh, Savjot Kaur, Mohan Jairath, Shailpreet Kaur Sidhu*, Amandeep Kaur

Volume : 10, Issue : 1, Year : 2023

Article Page : 21-25

https://doi.org/10.18231/j.agems.2023.006

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Abstract

Background: To curb SARS-CoV-2, various vaccines received Emergency Authorization Use by copious agencies. These vaccines are administered to health-care workers, front-line workers, elderly individuals and many others. Health care workers were the first to be administered with vaccines, thus, evaluating the antibody response helps to portray a picture of the burden of SARS-CoV-2 infection amid Health Care Workers.
Materials and Methods: The present study aimed to investigate the production of total antibodies against SARS-CoV-2 before and after vaccination (2 doses) among Health Care Workers along with associated factors. The present study was conducted on 60 healthcare workers as cases who got vaccinated for COVID-19. The semi-quantitative detection of anti-SARS-CoV-2 IgG Ab in the samples was detected using Erba Lisa COVID-19 total antibody indirect ELISA kit using standard protocol as described by the manufacturer.
Results: In the present study, co-morbidities such as hypertension was presented in only 8 (12.3%) individuals, diabetes in 4 (6.1%) and Coronary Artery Disease in 1 (1.5%). After first dose of administration, 86.67% HCWs were found seropositive for the anti-SARS-CoV-2 Ab while 13.33% were seronegative, however, after second dose 100% seroprevalence was observed amid HCWs. The statistical analysis depicted a significant difference (p<0> Conclusion: The present study provides important information on the detectable levels of antibodies induced by COVISHIELD against the SARS-CoV-2 which was independent of gender and age.

Keywords : SARS-CoV-2, Vaccine, COVISHIELD, Antibodies

How to cite : Singh K, Kaur S, Jairath M, Sidhu S K, Kaur A, Immunological response in health care workers post COVID-19 vaccination. Ann Geriatr Educ Med Sci 2023;10(1):21-25

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